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The ability of the brain to adapt to changes in signalling, neuroplasticity, is an important area of research, with a lot of interesting stuff going on. Probably long before figuring out how to attach a tail would be work for giving people limbs and senses they were born without and repairing related issues to brain damage, etc. While all the issues and questions wouldn't be solved before someone tries attaching such a tail, a lot of the difficulty questions would probably already have solid answers before hand from high priority work.

Also, the whole humans use only 10% of their brain thing is pretty much wrong.

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